Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial.
Identifieur interne : 000245 ( Main/Exploration ); précédent : 000244; suivant : 000246Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial.
Auteurs : Karolin Behringer [Allemagne] ; Helen Goergen [Allemagne] ; Felicitas Hitz [Suisse] ; Josée M. Zijlstra [Pays-Bas] ; Richard Greil [Autriche] ; Jana Markova [République tchèque] ; Stephanie Sasse [Allemagne] ; Michael Fuchs [Allemagne] ; Max S. Topp [Allemagne] ; Martin Soekler [Allemagne] ; Stephan Mathas [Allemagne] ; Julia Meissner [Allemagne] ; Martin Wilhelm [Allemagne] ; Peter Koch [Allemagne] ; Hans-Walter Lindemann [Allemagne] ; Enrico Schalk [Allemagne] ; Robert Semrau [Allemagne] ; Jan Kriz [Allemagne] ; Tom Vieler [Allemagne] ; Martin Bentz [Allemagne] ; Elisabeth Lange [Allemagne] ; Rolf Mahlberg [Allemagne] ; Andre Hassler [Allemagne] ; Martin Vogelhuber [Allemagne] ; Dennis Hahn [Allemagne] ; Jörg Mezger [Allemagne] ; Stefan W. Krause [Allemagne] ; Nicole Skoetz [Allemagne] ; Boris Böll [Allemagne] ; Bastian Von Tresckow [Allemagne] ; Volker Diehl [Allemagne] ; Michael Hallek [Allemagne] ; Peter Borchmann [Allemagne] ; Harald Stein [Allemagne] ; Hans Eich [Allemagne] ; Andreas Engert [Allemagne]Source :
- Lancet (London, England) [ 1474-547X ] ; 2015.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Bleomycin (administration & dosage), Dacarbazine (administration & dosage), Doxorubicin (administration & dosage), Female, Hodgkin Disease (drug therapy), Humans, Male, Middle Aged, Treatment Outcome, Vinblastine (administration & dosage).
- MESH :
- chemical , administration & dosage : Bleomycin, Dacarbazine, Doxorubicin, Vinblastine.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols.
- drug therapy : Hodgkin Disease.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
The role of bleomycin and dacarbazine in the ABVD regimen (ie, doxorubicin, bleomycin, vinblastine, and dacarbazine) has been questioned, especially for treatment of early-stage favourable Hodgkin's lymphoma, because of the drugs' toxicity. We aimed to investigate whether omission of either bleomycin or dacarbazine, or both, from ABVD reduced the efficacy of this regimen in treatment of Hodgkin's lymphoma.
DOI: 10.1016/S0140-6736(14)61469-0
PubMed: 25539730
Affiliations:
- Allemagne, Autriche, Pays-Bas, République tchèque, Suisse
- Bade-Wurtemberg, Bavière, Berlin, Bohême centrale, Canton de Berne, District de Basse-Franconie, District de Karlsruhe, District de Münster, District de Stuttgart, District de Tübingen, Hollande-Septentrionale, Rhénanie-du-Nord-Westphalie, Saxe-Anhalt, Schleswig-Holstein
- Amsterdam, Berlin, Berne, Heidelberg, Karlsruhe, Kiel, Magdebourg, Münster, Prague, Stuttgart, Tübingen, Wurtzbourg
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Le document en format XML
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Zijlstra</name><affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Greil, Richard" sort="Greil, Richard" uniqKey="Greil R" first="Richard" last="Greil">Richard Greil</name><affiliation wicri:level="1"><nlm:affiliation>Third Medical Department, Paracelcus Medical University, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Third Medical Department, Paracelcus Medical University, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Markova, Jana" sort="Markova, Jana" uniqKey="Markova J" first="Jana" last="Markova">Jana Markova</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Sasse, Stephanie" sort="Sasse, Stephanie" uniqKey="Sasse S" first="Stephanie" last="Sasse">Stephanie Sasse</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Fuchs, Michael" sort="Fuchs, Michael" uniqKey="Fuchs M" first="Michael" last="Fuchs">Michael Fuchs</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Topp, Max S" sort="Topp, Max S" uniqKey="Topp M" first="Max S" last="Topp">Max S. Topp</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Soekler, Martin" sort="Soekler, Martin" uniqKey="Soekler M" first="Martin" last="Soekler">Martin Soekler</name><affiliation wicri:level="3"><nlm:affiliation>University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Mathas, Stephan" sort="Mathas, Stephan" uniqKey="Mathas S" first="Stephan" last="Mathas">Stephan Mathas</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Meissner, Julia" sort="Meissner, Julia" uniqKey="Meissner J" first="Julia" last="Meissner">Julia Meissner</name><affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Wilhelm, Martin" sort="Wilhelm, Martin" uniqKey="Wilhelm M" first="Martin" last="Wilhelm">Martin Wilhelm</name><affiliation wicri:level="1"><nlm:affiliation>Klinikum Nürnberg, Nürnberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Nürnberg, Nürnberg</wicri:regionArea><wicri:noRegion>Nürnberg</wicri:noRegion><wicri:noRegion>Nürnberg</wicri:noRegion><wicri:noRegion>Nürnberg</wicri:noRegion></affiliation></author><author><name sortKey="Koch, Peter" sort="Koch, Peter" uniqKey="Koch P" first="Peter" last="Koch">Peter Koch</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Lindemann, Hans Walter" sort="Lindemann, Hans Walter" uniqKey="Lindemann H" first="Hans-Walter" last="Lindemann">Hans-Walter Lindemann</name><affiliation wicri:level="1"><nlm:affiliation>Katholisches Krankenhaus, Hagen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Katholisches Krankenhaus, Hagen</wicri:regionArea><wicri:noRegion>Hagen</wicri:noRegion><wicri:noRegion>Hagen</wicri:noRegion><wicri:noRegion>Hagen</wicri:noRegion></affiliation></author><author><name sortKey="Schalk, Enrico" sort="Schalk, Enrico" uniqKey="Schalk E" first="Enrico" last="Schalk">Enrico Schalk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Semrau, Robert" sort="Semrau, Robert" uniqKey="Semrau R" first="Robert" last="Semrau">Robert Semrau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Kriz, Jan" sort="Kriz, Jan" uniqKey="Kriz J" first="Jan" last="Kriz">Jan Kriz</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Vieler, Tom" sort="Vieler, Tom" uniqKey="Vieler T" first="Tom" last="Vieler">Tom Vieler</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik, Universitätsklinik Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Universitätsklinik Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Bentz, Martin" sort="Bentz, Martin" uniqKey="Bentz M" first="Martin" last="Bentz">Martin Bentz</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Städtisches Klinikum Karlsruhe, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Städtisches Klinikum Karlsruhe</wicri:regionArea><wicri:noRegion>Städtisches Klinikum Karlsruhe</wicri:noRegion><wicri:noRegion>Städtisches Klinikum Karlsruhe</wicri:noRegion><wicri:noRegion>Städtisches Klinikum Karlsruhe</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Elisabeth" sort="Lange, Elisabeth" uniqKey="Lange E" first="Elisabeth" last="Lange">Elisabeth Lange</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Hämatologie/Onkologie, Evangelisches Krankenhaus, Hamm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Hämatologie/Onkologie, Evangelisches Krankenhaus, Hamm</wicri:regionArea><wicri:noRegion>Hamm</wicri:noRegion><wicri:noRegion>Hamm</wicri:noRegion><wicri:noRegion>Hamm</wicri:noRegion></affiliation></author><author><name sortKey="Mahlberg, Rolf" sort="Mahlberg, Rolf" uniqKey="Mahlberg R" first="Rolf" last="Mahlberg">Rolf Mahlberg</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Krankenanstalt Mutterhaus d. Borromäerinnen, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Krankenanstalt Mutterhaus d. Borromäerinnen, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Hassler, Andre" sort="Hassler, Andre" uniqKey="Hassler A" first="Andre" last="Hassler">Andre Hassler</name><affiliation wicri:level="3"><nlm:affiliation>Zentrum für Innere Medizin, Hämatologie/Onkologie, Charité Campus Mitte, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Zentrum für Innere Medizin, Hämatologie/Onkologie, Charité Campus Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Vogelhuber, Martin" sort="Vogelhuber, Martin" uniqKey="Vogelhuber M" first="Martin" last="Vogelhuber">Martin Vogelhuber</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Universitätsklinik Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Universitätsklinik Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Hahn, Dennis" sort="Hahn, Dennis" uniqKey="Hahn D" first="Dennis" last="Hahn">Dennis Hahn</name><affiliation wicri:level="3"><nlm:affiliation>Klinik für Onkologie, Katharinenhospital, Stuttgart, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Onkologie, Katharinenhospital, Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Mezger, Jorg" sort="Mezger, Jorg" uniqKey="Mezger J" first="Jörg" last="Mezger">Jörg Mezger</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik-Hämatologie, Onkologie, Immunologie, Palliativmedizin, St. Vincentius-Kliniken gAG, Karlsruhe, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik-Hämatologie, Onkologie, Immunologie, Palliativmedizin, St. Vincentius-Kliniken gAG, Karlsruhe</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Karlsruhe</settlement></placeName></affiliation></author><author><name sortKey="Krause, Stefan W" sort="Krause, Stefan W" uniqKey="Krause S" first="Stefan W" last="Krause">Stefan W. Krause</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine 5, Haematology/Oncology, University of Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 5, Haematology/Oncology, University of Erlangen</wicri:regionArea><wicri:noRegion>University of Erlangen</wicri:noRegion><wicri:noRegion>University of Erlangen</wicri:noRegion><wicri:noRegion>University of Erlangen</wicri:noRegion></affiliation></author><author><name sortKey="Skoetz, Nicole" sort="Skoetz, Nicole" uniqKey="Skoetz N" first="Nicole" last="Skoetz">Nicole Skoetz</name><affiliation wicri:level="1"><nlm:affiliation>Cochrane Haematological Malignancies Group, Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cochrane Haematological Malignancies Group, Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Boll, Boris" sort="Boll, Boris" uniqKey="Boll B" first="Boris" last="Böll">Boris Böll</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Von Tresckow, Bastian" sort="Von Tresckow, Bastian" uniqKey="Von Tresckow B" first="Bastian" last="Von Tresckow">Bastian Von Tresckow</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Diehl, Volker" sort="Diehl, Volker" uniqKey="Diehl V" first="Volker" last="Diehl">Volker Diehl</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hallek, Michael" sort="Hallek, Michael" uniqKey="Hallek M" first="Michael" last="Hallek">Michael Hallek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Borchmann, Peter" sort="Borchmann, Peter" uniqKey="Borchmann P" first="Peter" last="Borchmann">Peter Borchmann</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Stein, Harald" sort="Stein, Harald" uniqKey="Stein H" first="Harald" last="Stein">Harald Stein</name><affiliation wicri:level="3"><nlm:affiliation>Berlin Reference Center for Lymphoma and Haematopathology, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin Reference Center for Lymphoma and Haematopathology, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Eich, Hans" sort="Eich, Hans" uniqKey="Eich H" first="Hans" last="Eich">Hans Eich</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Engert, Andreas" sort="Engert, Andreas" uniqKey="Engert A" first="Andreas" last="Engert">Andreas Engert</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany. Electronic address: a.engert@uni-koeln.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25539730</idno><idno type="pmid">25539730</idno><idno type="doi">10.1016/S0140-6736(14)61469-0</idno><idno type="wicri:Area/PubMed/Corpus">000268</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000268</idno><idno type="wicri:Area/PubMed/Curation">000268</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000268</idno><idno type="wicri:Area/PubMed/Checkpoint">000268</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000268</idno><idno type="wicri:Area/Ncbi/Merge">000751</idno><idno type="wicri:Area/Ncbi/Curation">000751</idno><idno type="wicri:Area/Ncbi/Checkpoint">000751</idno><idno type="wicri:Area/Main/Merge">000245</idno><idno type="wicri:Area/Main/Curation">000245</idno><idno type="wicri:Area/Main/Exploration">000245</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial.</title><author><name sortKey="Behringer, Karolin" sort="Behringer, Karolin" uniqKey="Behringer K" first="Karolin" last="Behringer">Karolin Behringer</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Goergen, Helen" sort="Goergen, Helen" uniqKey="Goergen H" first="Helen" last="Goergen">Helen Goergen</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hitz, Felicitas" sort="Hitz, Felicitas" uniqKey="Hitz F" first="Felicitas" last="Hitz">Felicitas Hitz</name><affiliation wicri:level="3"><nlm:affiliation>Cantonal Hospital of St Gallen, St Gallen, Switzerland and SAKK Swiss Group for Clinical Cancer Research, Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Cantonal Hospital of St Gallen, St Gallen, Switzerland and SAKK Swiss Group for Clinical Cancer Research, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Zijlstra, Josee M" sort="Zijlstra, Josee M" uniqKey="Zijlstra J" first="Josée M" last="Zijlstra">Josée M. Zijlstra</name><affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Greil, Richard" sort="Greil, Richard" uniqKey="Greil R" first="Richard" last="Greil">Richard Greil</name><affiliation wicri:level="1"><nlm:affiliation>Third Medical Department, Paracelcus Medical University, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Third Medical Department, Paracelcus Medical University, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Markova, Jana" sort="Markova, Jana" uniqKey="Markova J" first="Jana" last="Markova">Jana Markova</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Sasse, Stephanie" sort="Sasse, Stephanie" uniqKey="Sasse S" first="Stephanie" last="Sasse">Stephanie Sasse</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Fuchs, Michael" sort="Fuchs, Michael" uniqKey="Fuchs M" first="Michael" last="Fuchs">Michael Fuchs</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Topp, Max S" sort="Topp, Max S" uniqKey="Topp M" first="Max S" last="Topp">Max S. Topp</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Soekler, Martin" sort="Soekler, Martin" uniqKey="Soekler M" first="Martin" last="Soekler">Martin Soekler</name><affiliation wicri:level="3"><nlm:affiliation>University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Mathas, Stephan" sort="Mathas, Stephan" uniqKey="Mathas S" first="Stephan" last="Mathas">Stephan Mathas</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Meissner, Julia" sort="Meissner, Julia" uniqKey="Meissner J" first="Julia" last="Meissner">Julia Meissner</name><affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Wilhelm, Martin" sort="Wilhelm, Martin" uniqKey="Wilhelm M" first="Martin" last="Wilhelm">Martin Wilhelm</name><affiliation wicri:level="1"><nlm:affiliation>Klinikum Nürnberg, Nürnberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Nürnberg, Nürnberg</wicri:regionArea><wicri:noRegion>Nürnberg</wicri:noRegion><wicri:noRegion>Nürnberg</wicri:noRegion><wicri:noRegion>Nürnberg</wicri:noRegion></affiliation></author><author><name sortKey="Koch, Peter" sort="Koch, Peter" uniqKey="Koch P" first="Peter" last="Koch">Peter Koch</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Lindemann, Hans Walter" sort="Lindemann, Hans Walter" uniqKey="Lindemann H" first="Hans-Walter" last="Lindemann">Hans-Walter Lindemann</name><affiliation wicri:level="1"><nlm:affiliation>Katholisches Krankenhaus, Hagen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Katholisches Krankenhaus, Hagen</wicri:regionArea><wicri:noRegion>Hagen</wicri:noRegion><wicri:noRegion>Hagen</wicri:noRegion><wicri:noRegion>Hagen</wicri:noRegion></affiliation></author><author><name sortKey="Schalk, Enrico" sort="Schalk, Enrico" uniqKey="Schalk E" first="Enrico" last="Schalk">Enrico Schalk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Semrau, Robert" sort="Semrau, Robert" uniqKey="Semrau R" first="Robert" last="Semrau">Robert Semrau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Kriz, Jan" sort="Kriz, Jan" uniqKey="Kriz J" first="Jan" last="Kriz">Jan Kriz</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Vieler, Tom" sort="Vieler, Tom" uniqKey="Vieler T" first="Tom" last="Vieler">Tom Vieler</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik, Universitätsklinik Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Universitätsklinik Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Bentz, Martin" sort="Bentz, Martin" uniqKey="Bentz M" first="Martin" last="Bentz">Martin Bentz</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Städtisches Klinikum Karlsruhe, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Städtisches Klinikum Karlsruhe</wicri:regionArea><wicri:noRegion>Städtisches Klinikum Karlsruhe</wicri:noRegion><wicri:noRegion>Städtisches Klinikum Karlsruhe</wicri:noRegion><wicri:noRegion>Städtisches Klinikum Karlsruhe</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Elisabeth" sort="Lange, Elisabeth" uniqKey="Lange E" first="Elisabeth" last="Lange">Elisabeth Lange</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Hämatologie/Onkologie, Evangelisches Krankenhaus, Hamm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Hämatologie/Onkologie, Evangelisches Krankenhaus, Hamm</wicri:regionArea><wicri:noRegion>Hamm</wicri:noRegion><wicri:noRegion>Hamm</wicri:noRegion><wicri:noRegion>Hamm</wicri:noRegion></affiliation></author><author><name sortKey="Mahlberg, Rolf" sort="Mahlberg, Rolf" uniqKey="Mahlberg R" first="Rolf" last="Mahlberg">Rolf Mahlberg</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Krankenanstalt Mutterhaus d. Borromäerinnen, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Krankenanstalt Mutterhaus d. Borromäerinnen, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Hassler, Andre" sort="Hassler, Andre" uniqKey="Hassler A" first="Andre" last="Hassler">Andre Hassler</name><affiliation wicri:level="3"><nlm:affiliation>Zentrum für Innere Medizin, Hämatologie/Onkologie, Charité Campus Mitte, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Zentrum für Innere Medizin, Hämatologie/Onkologie, Charité Campus Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Vogelhuber, Martin" sort="Vogelhuber, Martin" uniqKey="Vogelhuber M" first="Martin" last="Vogelhuber">Martin Vogelhuber</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik, Universitätsklinik Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Universitätsklinik Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Hahn, Dennis" sort="Hahn, Dennis" uniqKey="Hahn D" first="Dennis" last="Hahn">Dennis Hahn</name><affiliation wicri:level="3"><nlm:affiliation>Klinik für Onkologie, Katharinenhospital, Stuttgart, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Onkologie, Katharinenhospital, Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Mezger, Jorg" sort="Mezger, Jorg" uniqKey="Mezger J" first="Jörg" last="Mezger">Jörg Mezger</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik-Hämatologie, Onkologie, Immunologie, Palliativmedizin, St. Vincentius-Kliniken gAG, Karlsruhe, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik-Hämatologie, Onkologie, Immunologie, Palliativmedizin, St. Vincentius-Kliniken gAG, Karlsruhe</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Karlsruhe</settlement></placeName></affiliation></author><author><name sortKey="Krause, Stefan W" sort="Krause, Stefan W" uniqKey="Krause S" first="Stefan W" last="Krause">Stefan W. Krause</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine 5, Haematology/Oncology, University of Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 5, Haematology/Oncology, University of Erlangen</wicri:regionArea><wicri:noRegion>University of Erlangen</wicri:noRegion><wicri:noRegion>University of Erlangen</wicri:noRegion><wicri:noRegion>University of Erlangen</wicri:noRegion></affiliation></author><author><name sortKey="Skoetz, Nicole" sort="Skoetz, Nicole" uniqKey="Skoetz N" first="Nicole" last="Skoetz">Nicole Skoetz</name><affiliation wicri:level="1"><nlm:affiliation>Cochrane Haematological Malignancies Group, Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cochrane Haematological Malignancies Group, Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Boll, Boris" sort="Boll, Boris" uniqKey="Boll B" first="Boris" last="Böll">Boris Böll</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Von Tresckow, Bastian" sort="Von Tresckow, Bastian" uniqKey="Von Tresckow B" first="Bastian" last="Von Tresckow">Bastian Von Tresckow</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Diehl, Volker" sort="Diehl, Volker" uniqKey="Diehl V" first="Volker" last="Diehl">Volker Diehl</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hallek, Michael" sort="Hallek, Michael" uniqKey="Hallek M" first="Michael" last="Hallek">Michael Hallek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Borchmann, Peter" sort="Borchmann, Peter" uniqKey="Borchmann P" first="Peter" last="Borchmann">Peter Borchmann</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Stein, Harald" sort="Stein, Harald" uniqKey="Stein H" first="Harald" last="Stein">Harald Stein</name><affiliation wicri:level="3"><nlm:affiliation>Berlin Reference Center for Lymphoma and Haematopathology, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin Reference Center for Lymphoma and Haematopathology, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Eich, Hans" sort="Eich, Hans" uniqKey="Eich H" first="Hans" last="Eich">Hans Eich</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Engert, Andreas" sort="Engert, Andreas" uniqKey="Engert A" first="Andreas" last="Engert">Andreas Engert</name><affiliation wicri:level="1"><nlm:affiliation>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne, Germany. Electronic address: a.engert@uni-koeln.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Hodgkin Study Group (GHSG), Department of Internal Medicine 1, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antineoplastic Combined Chemotherapy Protocols (adverse effects)</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Bleomycin (administration & dosage)</term><term>Dacarbazine (administration & dosage)</term><term>Doxorubicin (administration & dosage)</term><term>Female</term><term>Hodgkin Disease (drug therapy)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term><term>Vinblastine (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Bleomycin</term><term>Dacarbazine</term><term>Doxorubicin</term><term>Vinblastine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hodgkin Disease</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of bleomycin and dacarbazine in the ABVD regimen (ie, doxorubicin, bleomycin, vinblastine, and dacarbazine) has been questioned, especially for treatment of early-stage favourable Hodgkin's lymphoma, because of the drugs' toxicity. We aimed to investigate whether omission of either bleomycin or dacarbazine, or both, from ABVD reduced the efficacy of this regimen in treatment of Hodgkin's lymphoma.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Pays-Bas</li><li>République tchèque</li><li>Suisse</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>Berlin</li><li>Bohême centrale</li><li>Canton de Berne</li><li>District de Basse-Franconie</li><li>District de Karlsruhe</li><li>District de Münster</li><li>District de Stuttgart</li><li>District de Tübingen</li><li>Hollande-Septentrionale</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe-Anhalt</li><li>Schleswig-Holstein</li></region><settlement><li>Amsterdam</li><li>Berlin</li><li>Berne</li><li>Heidelberg</li><li>Karlsruhe</li><li>Kiel</li><li>Magdebourg</li><li>Münster</li><li>Prague</li><li>Stuttgart</li><li>Tübingen</li><li>Wurtzbourg</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Behringer, Karolin" sort="Behringer, Karolin" uniqKey="Behringer K" first="Karolin" last="Behringer">Karolin Behringer</name></noRegion><name sortKey="Bentz, Martin" sort="Bentz, Martin" uniqKey="Bentz M" first="Martin" last="Bentz">Martin Bentz</name><name sortKey="Boll, Boris" sort="Boll, Boris" uniqKey="Boll B" first="Boris" last="Böll">Boris Böll</name><name sortKey="Borchmann, Peter" sort="Borchmann, Peter" uniqKey="Borchmann P" first="Peter" last="Borchmann">Peter Borchmann</name><name sortKey="Diehl, Volker" sort="Diehl, Volker" uniqKey="Diehl V" first="Volker" last="Diehl">Volker Diehl</name><name sortKey="Eich, Hans" sort="Eich, Hans" uniqKey="Eich H" first="Hans" last="Eich">Hans Eich</name><name sortKey="Engert, Andreas" sort="Engert, Andreas" uniqKey="Engert A" first="Andreas" last="Engert">Andreas Engert</name><name sortKey="Fuchs, Michael" sort="Fuchs, Michael" uniqKey="Fuchs M" first="Michael" last="Fuchs">Michael Fuchs</name><name sortKey="Goergen, Helen" sort="Goergen, Helen" uniqKey="Goergen H" first="Helen" last="Goergen">Helen Goergen</name><name sortKey="Hahn, Dennis" sort="Hahn, Dennis" uniqKey="Hahn D" first="Dennis" last="Hahn">Dennis Hahn</name><name sortKey="Hallek, Michael" sort="Hallek, Michael" uniqKey="Hallek M" first="Michael" last="Hallek">Michael Hallek</name><name sortKey="Hassler, Andre" sort="Hassler, Andre" uniqKey="Hassler A" first="Andre" last="Hassler">Andre Hassler</name><name sortKey="Koch, Peter" sort="Koch, Peter" uniqKey="Koch P" first="Peter" last="Koch">Peter Koch</name><name sortKey="Krause, Stefan W" sort="Krause, Stefan W" uniqKey="Krause S" first="Stefan W" last="Krause">Stefan W. Krause</name><name sortKey="Kriz, Jan" sort="Kriz, Jan" uniqKey="Kriz J" first="Jan" last="Kriz">Jan Kriz</name><name sortKey="Lange, Elisabeth" sort="Lange, Elisabeth" uniqKey="Lange E" first="Elisabeth" last="Lange">Elisabeth Lange</name><name sortKey="Lindemann, Hans Walter" sort="Lindemann, Hans Walter" uniqKey="Lindemann H" first="Hans-Walter" last="Lindemann">Hans-Walter Lindemann</name><name sortKey="Mahlberg, Rolf" sort="Mahlberg, Rolf" uniqKey="Mahlberg R" first="Rolf" last="Mahlberg">Rolf Mahlberg</name><name sortKey="Mathas, Stephan" sort="Mathas, Stephan" uniqKey="Mathas S" first="Stephan" last="Mathas">Stephan Mathas</name><name sortKey="Meissner, Julia" sort="Meissner, Julia" uniqKey="Meissner J" first="Julia" last="Meissner">Julia Meissner</name><name sortKey="Mezger, Jorg" sort="Mezger, Jorg" uniqKey="Mezger J" first="Jörg" last="Mezger">Jörg Mezger</name><name sortKey="Sasse, Stephanie" sort="Sasse, Stephanie" uniqKey="Sasse S" first="Stephanie" last="Sasse">Stephanie Sasse</name><name sortKey="Schalk, Enrico" sort="Schalk, Enrico" uniqKey="Schalk E" first="Enrico" last="Schalk">Enrico Schalk</name><name sortKey="Semrau, Robert" sort="Semrau, Robert" uniqKey="Semrau R" first="Robert" last="Semrau">Robert Semrau</name><name sortKey="Skoetz, Nicole" sort="Skoetz, Nicole" uniqKey="Skoetz N" first="Nicole" last="Skoetz">Nicole Skoetz</name><name sortKey="Soekler, Martin" sort="Soekler, Martin" uniqKey="Soekler M" first="Martin" last="Soekler">Martin Soekler</name><name sortKey="Stein, Harald" sort="Stein, Harald" uniqKey="Stein H" first="Harald" last="Stein">Harald Stein</name><name sortKey="Topp, Max S" sort="Topp, Max S" uniqKey="Topp M" first="Max S" last="Topp">Max S. Topp</name><name sortKey="Vieler, Tom" sort="Vieler, Tom" uniqKey="Vieler T" first="Tom" last="Vieler">Tom Vieler</name><name sortKey="Vogelhuber, Martin" sort="Vogelhuber, Martin" uniqKey="Vogelhuber M" first="Martin" last="Vogelhuber">Martin Vogelhuber</name><name sortKey="Von Tresckow, Bastian" sort="Von Tresckow, Bastian" uniqKey="Von Tresckow B" first="Bastian" last="Von Tresckow">Bastian Von Tresckow</name><name sortKey="Wilhelm, Martin" sort="Wilhelm, Martin" uniqKey="Wilhelm M" first="Martin" last="Wilhelm">Martin Wilhelm</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Hitz, Felicitas" sort="Hitz, Felicitas" uniqKey="Hitz F" first="Felicitas" last="Hitz">Felicitas Hitz</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Zijlstra, Josee M" sort="Zijlstra, Josee M" uniqKey="Zijlstra J" first="Josée M" last="Zijlstra">Josée M. Zijlstra</name></region></country><country name="Autriche"><noRegion><name sortKey="Greil, Richard" sort="Greil, Richard" uniqKey="Greil R" first="Richard" last="Greil">Richard Greil</name></noRegion></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Markova, Jana" sort="Markova, Jana" uniqKey="Markova J" first="Jana" last="Markova">Jana Markova</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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